The average vitamin or mineral should not affect your antidepressant's functionality or your health. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. 2019;11(12):e6466. View abstract. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. Vitamins and Supplements That Should Not Be Taken Together - Health View abstract. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. We have said that the elements ashwagandha meds of will ashwagandha interact with diabetic meds cause, ashwagandha interact diabetic principle and ontology are the objects of our research. View abstract. View abstract. View abstract. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. 2013;12(4):312-22. Curr Clin Pharmacol. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Researchers of the study believed that these results were due to the ability of ashwagandha to moderate the body's stress response. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. Int Ayurvedic Med J 2013;1(5):1-7. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Indian J Psychol Med. Although ashwagandha is mainly considered safe, side effects may be possible. View abstract. View abstract. Underactive Thyroid. Effect of a medicinal plant (Passiflora incarnataL) on sleep. Fortunately, no cases resulted in liver failure, and all recovered. Ashwagandha may be able to help with insomnia. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. However, there is concern that herbs like ashwagandha may have interactions that have . The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. View abstract. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Doses higher than that may interact with lexapro, or produce more pronounced effects. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. J Funct Morphol Kinesiol. Medically reviewed by Drugs.com. Phytother Res 2022. View abstract. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. 2021;270:113766. Some products may not mix well with other drugs or natural products. National Institutes of Health Office of Dietary Supplements. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? View abstract. Is it safe to take ashwagandha every day? Read our. . 2016;928:329-373. doi:10.1007/978-3-319-41334-1_14. Ashwagandha can also interact with some medications and affect how they work. Ashwagandha is an evergreen shrub that grows in Asia and Africa. In comparison, a small human trial published in 2022 showed additional proof that ashwagandha may be helpful for people living with anxiety. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. This is called a medicine interaction. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Ashwagandha may be used for anxiety due to its perceived anti-inflammatory and antioxidant properties. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Phytother Res. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Next Steps to Take, Understanding Your Childs Life With ADHD. levothyroxine, desiccated thyroid) could potentially increase thyroid hormone levels too much, increasing the risk of side effects. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Its effects on arterial blood pressure in anaesthetized dogs. Ashwagandha has been traditionally used for anxiety, insomnia, aging, and other conditions that may be exacerbated by stress. Sleep Sci. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Antidepressants come in various forms. They also are not very good drugs, because they have multiple potentially . Ashwagandha might cause sleepiness and slowed breathing. This article provides a review of the potential uses of ashwagandha. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Take extra care and check with your doctor if you have: Signs of a very bad reaction. Akhgarjand C, Asoudeh F, Bagheri A, et al. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. You will need to talk about the benefits and risks of using this natural product. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. Curr Res Toxicol. Now, most studies suggest that ashwagandha doesn't have significant blood pressure lowering effects, so the interaction here is thought to be relatively mild. J Clin Psychiatry. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. As with many other herbal supplements, little research is available on possible interactions. 4. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. Acta Pol.Pharm. Monitor your blood pressure closely. Ashwaganda and Xanax Interactions Checker - Drugs.com Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Durg S, Bavage S, Shivaram SB. 1965;9(1):9-15. No, that's not true all the time. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. J Ethnopharmacol 1999;67:27-35. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). Acta Oncol. 2019;11(9):e5797. A variety of of vitamins and nutritional supplements have been shown to help treat depression. Verywell Health's content is for informational and educational purposes only. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. Hydroxyzine has moderate interactions with at least 207 different drugs. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. 2013;2013:571420. Created for people with ongoing healthcare needs but benefits everyone. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Consult your doctor before taking ashwagandha if you use digoxin. Indian J Pharmacol. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. Ancient herb eases stress, boosts memory, and may help you lose weight. As a general rule of thumb, never exceed the recommended dose of ashwagandha. . of signs you need emergency medical attention or call 911. 1998;20(1):191-198. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Does Ashwagandha Interact With Prescription Drugs? 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. View abstract. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. While supplement and drug-induced serotonin syndrome poses a major risk for people taking SSRIs, other antidepressants can require stricter dietary changes. It may also interact with other herbs, supplements, and even foods. Panda S, Kar A. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. However, SSRIs don't work for everyone, and other antidepressants work via different pathways in your body. Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. Ashwagandha Uses, Benefits & Side Effects - Drugs.com losartan, valsartan, telmisartan), Beta-Blockers (e.g. View abstract. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Read More. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. 2004;42(12):2015-2020. View abstract. Efficacy of Withania somnifera supplementation on adult's cognition and mood. View abstract. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Sud Khyati S, Thaker B. Some ontologies are recognized by everyone, diabetes insipidus medication side effects and some are recognized noni lower blood sugar as ontologies only by . Synthroid is not known to interact with these supplements. View abstract. Read more: 15 Celebrities Who Struggle With Anxiety and Depression. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Serotonin syndrome can even result in death. View abstract. Acta Nerv Super 1990;32(1):1-5. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Begum, V. H. and Sadique, J. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Always talk with a healthcare provider before starting any new supplement regimen. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Ethnopharmacol. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. View abstract. 2001;75(2-3):165-168. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the . There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. 2022;13(2):100510. doi:10.1016/j.jaim.2021.08.003, Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Ashwagandha's cortisol-lowering effects may be responsible. View abstract. J Ethnopharmacol. drugs for diabetes and blood pressure). Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. ; Vomiting and nausea. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Ahumada F, Aspee F, Wikman G, and et al. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. In general, Ashwagandha is thought to be safe when used in moderate amounts. Altern Med Rev 2000;5:334-46. J Diet Suppl. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Synthroid and interactions: Food, alcohol, and more - Medical News Today If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. For more information on drug interactions, visit the RxList Drug Interaction Checker. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place.