I don't know how many more cycles I can do as my emotional reserve is running low. This can be done! I have expressed my concern but my RE believes it is more about the pattern. Was just curious if the percentages of a live birth increase after a positive pregnancy test. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Sorry to hear about your recent cycle. (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). It took me 3 fresh + 3 frozen but I finally did get my baby. But I do have a friend who had 1 embryo shipped from Utah to California for an FET and it was a different clinic that handled the FET. Good luck and wishing baby dust your way soon! Like embryo grades in the previous section, it looks like IVF with PGS success rates may vary based on how fast the embryo develops, particularly for Day 7. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). I did PGS testing. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Did your RE have you take anything other than progesterone and estrogen and aspirin? My lining a week before transfer was 6.8, but trilaminar lining was present. Terms are highlighted every 3rd time to avoid repetition. If you have not I would suggest an embryo scratch/biopsy before your next FET. I actually didn't do acupuncture the second cycle, but I was in great shape. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. great to know! Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). And congrats on your little girl! My current success was a FET with NO meds except vaginal progesterone. FAILED FIRST FET (Chemical Pregnancy). I have a Day 7/PGS Euploid Does it still matter? I honestly wish I had but thats all hindsight now knowing what I knew. I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. Thankful for these forums! Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. Hi all, Does this harm the embryo or reduce its potential for success? Then for my second FET we did an unmedicated FET and it worked. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Disclaimer: Any studies presented here may be contradicted by other studies. This is all so hard and stressful. what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? My 2nd also failed and I had them do a thrombophilia panel on me and found I had a MTHFR mutation so we added folgard and he adjusted my days on progesterone and in addition to the suppositories I did the shots as well. Gearing up for FET They also reported the number ofblastsbiopsied. PGS or Transfer 2 embryos? - Infertility - Inspire I only have embryo left ugh . no, I just took those 3. 5AB euploid embryo. So sorry this happened and good luck to you. After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. It kind of makes me wonder what they get out of their alternative recommendations. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. Took THREE rounds of antibiotics for mine to clear. It worked and now I'm 24 weeks pregnant with twins! My clinic does allow each patient to continue with one retrieval with only 1-2 follicles, however, for cost reasons since we're doing ICSI and PGS testing I'm considering cancelling the cycle. Did your doctor have your SO go through the rounds of antibiotics as well? For now its probably best to avoid having to thaw and biopsy if possible. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. So they were both frozen on Day 6? It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. We PGS tested the whole batch of embryos at once at the end of all the retrievals. I am so so sorry. Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. Reply Share React AMB425 Sep 2, 2016 11:01 AM MENTS my 3rd FET was a success end MENTS. Thanks in advance! We were hoping for a Christmas miracle however that was short lived. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. We had 30 eggs retrieval. Well also look at the chances of getting a euploid based on age, the impact of embryo grade and the day it was frozen (Day 5, 6 or 7), and how rebiopsies or thaw and biopsies fare for success rates. For these groups, about 50% of biopsies had noeuploidembryos. I did do another round of IVF and am now 17 weeks pregnant. Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. 5AB euploid embryo. Do you think it's worth it as last time I had a medicated cycle and it was a . For the autoimmune stuff above I was tested by Alexander Kofinas. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. (2017)had similar results to above (aCGH, women <35): Capalbo et al. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. I also did Neupogen but they still wanted to test for autoimmune disorders. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! Now I wonder if that could have been the culprit. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. I had another hysteroscopy after my chemical but b/c it had been nearly 2 years since I had one when i started IVF. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. It wouldnt be going far at least. We decided to start with IUI with clomid which resulted in another chemical pregnancy. We are so happy about that, we just want this one to be the one. Im trying not to fixate on my last embryo being a day 7. What Is a Chemical Pregnancy: Early Miscarriage - Healthline I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. I refused to go into another FET without doing some test or adjusting 1 variable, otherwise it was just repeating the same mistakes in my mind. Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. Nov 2, 2016 8:12 AM. 2nd was an FET that was a chemical, likely due to an embryo issue, even though it was graded highest. , ERA was a game changer for me! Yes, and I believe it was due to doctor negligence. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. Patients often hear "PGS-normal embryos have a 60 - 70% success rate." But that is on a per-transfer basis. Hi, i didnt have chemicals, I had bfn for my first two transfers. How many of your embryos made it to day 5? The Bump Im assuming you had no issues shipping yours? I can totally see not doing it though. The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. Last January we found out we were pregnant but had a miscarriage at 7 weeks. Its basically a mock FET but instead of transferring an embryo they take a biopsy of your uterus to see if it was ready for implantation at the time or needs more/less progesterone. A 2019 multicenter and international RCT (the STAR trial) compared euploid and untested embryo transfers. I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Why did I miscarry a normal embryo? History , thats definitely worth looking into as well! Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). Every positive thing helps! To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. We spent well over 45K to get to this point. What are the miscarriage rates with PGT embryos? : r/IVF - Reddit Check here for the full. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. Looking for anyone who has had recurrent chemical pregnancies and then found success. Segmental aneuploids: the main source for PGT-A false positives? Going into my second round of IVF I was doubting anything would work. And mosaics are in between, with low/moderate level mosaics (<50% aneuploid cells) performing nearly the same as euploids. About 7 months later I transferred a day 7. However, I just recently gave birth, so dont give up there are still lots of reasons to be hopeful esp if you make pgs normal blasts. My previous cycle where I started the prep medications (minivelle and ganirelix) was shorter (23 days) than my typical cycle (25-28) days. MENTS We were devastated after our first pgs transfer ended in a chemical, and unfortunately we went on to have one more before finding success. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. I just found out today that I've only got 2 larger follicles and 3 smaller ones that are growing but are quite behind the 2 larger ones. So what gives now?? Go figure, right?! Just trying to figure out what else I can do as I only have one embryo left. Please specify a reason for deleting this reply from the community. Inconclusive or No Result biopsies may require a second round of biopsy aka a rebiopsy. We timed everything to my cycle. Did you ever go through with your day 7 FET? Meaning that if you begin a cycle, retrieve eggs, produce embryos, then do PGS testing, and at least one embryo comes back normal, 60 - 70% of the time it will lead to a live birth. Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. They biopsied those 2 embryos and send off the cells for PGS testing. I think the ERA is a great idea too. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. Good luck and feel free to PM me. thats a great suggestion! Ill also update this blog to include that info. HCG was 24 Friday and yesterday went down to 16. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. Hello. This ended up working for me after my biochemical pregnancy. (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. hang in there. Both Chemical pregnancies my lining was under 7. Check here for the full glossary (please excuse the repeated terms!). A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Once they see it on an U/S, I think it becomes a clinical pregnancy. I know how hard this all is. Im willing to try anything :) thanks for sharing! Fast Facts About PGS Testing Risks. Best of luck to you. I had a chemical pregnancy last November after a fresh transfer. Multiple chemical pregnancies from embryos that had been PGS tested 4 PGT-M and PGT-A vs. Prenatal Testing In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. But after this chemical pregnancy from our PGS embryo, I have a gut feeling there is something else at play and am pushing my doctor for additional testing before another transfer since we only have 3 embryos left after 2 IVF cycles. I have a whole page dedicated to mosaic embryos. I actually didnt have embryos to bring with me when we switched. 8 Things I've Learned From 4 Failed IVF Cycles - SELF Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. Can you tell me the success rate? Id say if you feel you want the extra testing, push for it. Its so heartbreaking but Im trying to find some hope so I can move forward. Thanks! Can I ask why they didn't test them on Day 5? Your experience gives me hope so thank you for sharing , - Estradiol patches and to apply 4 of them and change them every 2 days, - progesterone 200mg suppository morning and evening. Or a fully aneuploid embryo? Has anyone ever gotten lucky and had all embryos come back normal? After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. ALL THREE DID!!! If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Consult with your doctor before making any treatment changes. Criticisms of PGS - FertilityIQ Your post will be hidden and deleted by moderators. We are currently looking to use a gestational surrogate in Texas. When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Bradley et al. So what if the embryos are euploid? I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. And since then Ive had medical issues that havent allowed me to try again until last month. In a small study,Bradley et al. A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus. 2018).